29 Substructure descriptors; 0 new.

Antibacterial

Teratogen

Carcinogenic

Antibiotic

Carcinogenic, group 3

Carcinogenic, female rats

Carcinogenic, male rats

CYP2 substrate

Carcinogenic, female mice

Carcinogenic, male mice

CYP3A substrate

CYP2B substrate

CYP1A substrate

CYP1A1 substrate

CYP2C substrate

CYP2C11 substrate

Diamine N-acetyltransferase inhibitor

28 Possible activities at Pa > 50%

Pa Pi Activity:

0,970 0,002 Antiprotozoal (Toxoplasma)

0,938 0,002 Dihydropteroate synthase inhibitor

0,881 0,004 Para amino benzoic acid antagonist

0,791 0,049 Hematotoxic

0,758 0,018 Antineoplastic (colorectal cancer)

0,795 0,073 Prolyl aminopeptidase inhibitor

0,708 0,041 Dopamine D4 agonist

0,699 0,032 Antineoplastic (brain cancer)

0,677 0,029 Torsades de pointes

0,656 0,041 Oxidoreductase inhibitor

0,621 0,015 Prostaglandin H2 antagonist

0,616 0,011 Cytochrome P450 CYP2C9 inhibitor

0,651 0,055 Arrhythogenic

0,635 0,042 Laccase inhibitor

0,598 0,020 Antiviral (Picornavirus)

0,599 0,037 Thiol oxidase inhibitor

0,575 0,048 Cathepsin G inhibitor

0,569 0,044 Gingipain K inhibitor

0,536 0,012 Antidiabetic

0,558 0,037 CYP3A2 substrate

0,555 0,035 Antiinflammatory, intestinal

0,506 0,006 HIV-1 integrase (3'-Processing) inhibitor

0,505 0,025 Prostaglandin E1 antagonist

0,514 0,036 Collagen inhibitor

0,521 0,044 2,3-Dihydroxybenzoate 2,3-dioxygenase inhibitor

0,529 0,059 Indole 2,3-dioxygenase inhibitor

0,512 0,047 Cytochrome P450 inhibitor

0,531 0,203 Antinephritic